Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis

Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis

Abstract Background Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a...

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Bibliographic Details
Main Authors: Yue Chang, Min Hao, Ru Jia, Yihui Zhao, Yixuan Cai, Yun Liu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
Endometrial cancer
miR-492
Metapristone
Klf5
Nrf1
Online Access:https://doi.org/10.1186/s12935-020-01682-1

Internet

https://doi.org/10.1186/s12935-020-01682-1

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