Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice

Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice

BackgroundThe hepatoprotective effect of interleukin 22 (IL-22) has been reported in several models of liver injuries, including alcohol-associated liver disease (ALD). However, the intestinal role of IL-22 in alcoholic hepatitis remains to be elucidated.MethodsIntestinal IL-22 levels were measured...

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Bibliographic Details
Main Authors: Ruichao Yue, Xiaoyuan Wei, Liuyi Hao, Haibo Dong, Wei Guo, Xinguo Sun, Jiangchao Zhao, Zhanxiang Zhou, Wei Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
Alcohol-associated liver disease
IL-22
STAT3
antimicrobial peptide
microbiota
PAMP translocation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289356/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289356/full

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