Quinolone Resistance Reversion by Targeting the SOS Response

ABSTRACT Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli representing multiple levels of quinolone res...

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Bibliographic Details
Main Authors: E. Recacha, J. Machuca, P. Díaz de Alba, M. Ramos-Güelfo, F. Docobo-Pérez, J. Rodriguez-Beltrán, J. Blázquez, A. Pascual, J. M. Rodríguez-Martínez
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mBio.00971-17