Mathematical modelling of OAS2 activation by dsRNA and effects of dsRNA lengths

Mathematical modelling of OAS2 activation by dsRNA and effects of dsRNA lengths

The activation of 2'-5'-oligoadenylate synthetase (OAS) enzymes by direct interaction with viral double-stranded RNA (dsRNA) is a key part of the innate immune response to viral infection. A downstream effect of the OAS-dsRNA interaction is to degrade the single-stranded RNA to prevent the...

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Bibliographic Details
Main Authors: Deokro Lee, Amit Koul, Nikhat Lubna, Sean A. McKenna, Stéphanie Portet
Format: Article
Language:English
Published: AIMS Press 2021-04-01
Series:AIMS Mathematics
Subjects:
oas2
dsrna
lengths
concentrations
enzyme activation
mathematical modelling
enzymatic activity
Online Access:http://www.aimspress.com/article/doi/10.3934/math.2021351?viewType=HTML

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http://www.aimspress.com/article/doi/10.3934/math.2021351?viewType=HTML

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