Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study

Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study

The biological properties of therapeutic peptides, such as their pharmacokinetics and pharmacodynamics, are correlated with their structure and aggregation properties. Herein, we studied the aggregation properties of a therapeutic peptide (CIGB-814), currently in phase 2 clinical trial, for the trea...

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Bibliographic Details
Main Authors: Rita Cimino, Marco Savioli, Noemi Ferrante Carrante, Ernesto Placidi, Hilda Garay-Perez, Matilde López-Abad, Alexis Musacchio Lasa, Maria Del Carmen Domínguez-Horta, Emanuela Gatto, Francesca Cavalieri, Gianfranco Bocchinfuso, Mariano Venanzi
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-01-01
Series:ChemPhysMater
Subjects:
Molecular dynamics of peptide oligomers
Peptide aggregation
Peptide fibrils
Peptide nanostructures
Therapeutic peptides
Treatment of rheumatoid arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2772571521000073

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http://www.sciencedirect.com/science/article/pii/S2772571521000073

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