Leptolysin, a Leptospira secreted metalloprotease of the pappalysin family with broad-spectrum activity

Leptolysin, a Leptospira secreted metalloprotease of the pappalysin family with broad-spectrum activity

Extracellular proteolytic enzymes are produced by a variety of pathogenic microorganisms, and contribute to host colonization by modulating virulence. Here, we present a first characterization of leptolysin, a Leptospira metalloprotease of the pappalysin family identified in a previous exoproteomic...

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Bibliographic Details
Main Authors: Daniella dos Santos Courrol, Cristiane Castilho Fernandes da Silva, Luan Gavião Prado, Rosa Maria Chura-Chambi, Ligia Morganti, Gisele Oliveira de Souza, Marcos Bryan Heinemann, Lourdes Isaac, Fernando Paiva Conte, Fernanda Calheta Vieira Portaro, Rodrigo Nunes Rodrigues-da-Silva, Angela Silva Barbosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
leptolysin
pappalysin-1 domain protein
Leptospira
proteolytic activity
extracellular matrix degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.966370/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.966370/full

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