Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine deamidation, and aspartic acid isomerization....

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Bibliographic Details
Main Authors: Tao Liu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Jun Li, Weizhu Qian, Huaizu Guo, Xinli Zhou, Sheng Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Chemistry
Subjects:
deamidation
succinimide
golimumab
efficacy
framework region
multi-attribute method
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.826923/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.826923/full

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