Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2

Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2

The proviral integration site for moloney murine leukemia virus 1 (Pim1) is a serine/threonine kinase and able to promote cell proliferation, survival and drug resistance. Overexpression of Pim1 has been observed in many cancer types and is associated with the poor prognosis of breast cancer. Howeve...

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Bibliographic Details
Main Authors: Bo-Wei Wang, Chih-Hao Huang, Liang-Chih Liu, Fang-Ju Cheng, Ya-Ling Wei, Yueh-Ming Lin, Yu-Fei Wang, Ching-Ting Wei, Yeh Chen, Yun-Ju Chen, Wei-Chien Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
HER2
lapatinib
drug resistance
breast cancer
PIM1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.614673/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.614673/full

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