Claulansine F–Donepezil Hybrids as Anti-Alzheimer’s Disease Agents with Cholinergic, Free-Radical Scavenging, and Neuroprotective Activities

Claulansine F–Donepezil Hybrids as Anti-Alzheimer’s Disease Agents with Cholinergic, Free-Radical Scavenging, and Neuroprotective Activities

The multifactorial nature of Alzheimer’s disease (AD) calls for the development of multitarget agents addressing key pathogenic processes. A total of 26 Claulansine F–donepezil hybrids were designed and synthesized as multitarget drugs. Among these compounds, six compounds exhibited excellent acetyl...

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Bibliographic Details
Main Authors: Yingda Zang, Ke Liu, Weiping Wang, Chuangjun Li, Jie Ma, Jingzhi Yang, Xinyi Chen, Xiaoliang Wang, Dongming Zhang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
Alzheimer’s disease
Claulansine F–donepezil hybrids
AChE inhibitory activity
free-radical scavenging activity
neuroprotective effects
Online Access:https://www.mdpi.com/1420-3049/26/5/1303

Internet

https://www.mdpi.com/1420-3049/26/5/1303

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