Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation

Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation

Summary: T cells are the most common immune cells in atherosclerotic plaques, and the function of T cells can be altered by fatty acids. Here, we show that pre-exposure of CD4+ T cells to oleic acid, an abundant fatty acid linked to cardiovascular events, upregulates core metabolic pathways and prom...

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Bibliographic Details
Main Authors: Nathalie A. Reilly, Friederike Sonnet, Koen F. Dekkers, Joanneke C. Kwekkeboom, Lucy Sinke, Stan Hilt, Hayat M. Suleiman, Marten A. Hoeksema, Hailiang Mei, Erik W. van Zwet, Bart Everts, Andreea Ioan-Facsinay, J. Wouter Jukema, Bastiaan T. Heijmans
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Physiology
Human metabolism
Immunology
Cell biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422400717X

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http://www.sciencedirect.com/science/article/pii/S258900422400717X

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