Biosynthesis of plant hemostatic dencichine in Escherichia coli

Biosynthetic pathway of dencichine, a plant derived nature product that has found various pharmacological applications, is still elusive. Here, the authors design artificial pathways through retro-biosynthesis approaches and achieve its efficient production in E. coli by systematic metabolic and enz...

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Bibliographic Details
Main Authors: Wenna Li, Zhao Zhou, Xianglai Li, Lin Ma, Qingyuan Guan, Guojun Zheng, Hao Liang, Yajun Yan, Xiaolin Shen, Jia Wang, Xinxiao Sun, Qipeng Yuan
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33255-3