Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas

Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase respo...

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Bibliographic Details
Main Authors: Cameron D. Lindsay, Morris A. Kostiuk, Jeff Harris, Daniel A. O’Connell, Hadi Seikaly, Vincent L. Biron
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Clinical Epigenetics
Subjects:
Histone methyltransferase
EZH2
Human papillomavirus
Oropharyngeal squamous cell carcinoma
Epigenetic
Online Access:http://link.springer.com/article/10.1186/s13148-017-0390-y

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http://link.springer.com/article/10.1186/s13148-017-0390-y

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