Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

The immunoglobulin-like lectin receptor CD169 (Siglec-1) mediates the capture of HIV-1 by activated dendritic cells (DCs) through binding to sialylated ligands. These interactions result in a more efficient virus capture as compared to resting DCs, although the underlying mechanisms are poorly under...

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Bibliographic Details
Main Authors: Enric Gutiérrez-Martínez, Susana Benet Garrabé, Nicolas Mateos, Itziar Erkizia, Jon Ander Nieto-Garai, Maier Lorizate, Kyra JE Borgman, Carlo Manzo, Felix Campelo, Nuria Izquierdo-Useros, Javier Martinez-Picado, Maria F Garcia-Parajo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
actin cytoskeleton
receptor nanoclustering
super-resolution microscopy
single-particle tracking
Online Access:https://elifesciences.org/articles/78836

Internet

https://elifesciences.org/articles/78836

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