One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea. Selected 2-thiooxo and 2-imino analogs were also obtained with the Biginelli reaction from thiourea and guanidine hydroc...

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Bibliographic Details
Main Authors: Jessica Bais, Fabio Benedetti, Federico Berti, Iole Cerminara, Sara Drioli, Maria Funicello, Giorgia Regini, Mattia Vidali, Fulvia Felluga
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
Alzheimer’s disease
dihydropyrimidinones
Biginelli reaction
β-secretase
BACE-1 inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/18/4152

Internet

https://www.mdpi.com/1420-3049/25/18/4152

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