Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis

Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis

The present study aimed to investigate whether dexmedetomidine (Dex) exerts cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury (MIRI) was induced in Sprague-Dawley rats in Langendorff preparation. The hemodynamic parameters were recorded. Triphenyltetrazol...

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Bibliographic Details
Main Authors: Zhuoran Wang, Mengran Yao, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi Qian, Yu Zhao, Jinqiao Qian
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Myocardial ischemia/reperfusion injury
Dexmedetomidine
Ferroptosis
AMPK/GSK-3β
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222009611

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http://www.sciencedirect.com/science/article/pii/S0753332222009611

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