Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation.
Although keratinocyte-derived neuropeptide neuromedin U (NMU) mediates the proinflammatory effects of innate-type mast cell activation, no information is available on the physiological roles. Here, to investigate the effects of NMU on IgE-mediated allergic skin inflammation, we determined whether Ig...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4963095?pdf=render |
| _version_ | 1817986157555744768 |
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| author | Yoshiko Mizukawa Takaaki Doi Yoshimi Yamazaki Akihiko Kudo Tetsuo Shiohara |
| author_facet | Yoshiko Mizukawa Takaaki Doi Yoshimi Yamazaki Akihiko Kudo Tetsuo Shiohara |
| author_sort | Yoshiko Mizukawa |
| collection | DOAJ |
| description | Although keratinocyte-derived neuropeptide neuromedin U (NMU) mediates the proinflammatory effects of innate-type mast cell activation, no information is available on the physiological roles. Here, to investigate the effects of NMU on IgE-mediated allergic skin inflammation, we determined whether IgE-mediated inflammation associated with severe scratching was induced in Nmu-/- mice administered repeated hapten applications to the ear or footpad. Dry skin was induced by targeted deletion of Nmu. Mice administered repeated hapten application developed IgE-mediated allergic inflammation characterized by severe scratching and increased serum IgE levels only when the ear, and not the footpad, was subjected to scratching, indicating that depletion of NMU from the epidermis alone does not drive such allergic inflammation. Thus, the susceptibility of Nmu-/- mice to allergic inflammation depends primarily on scratching dry skin. Further, allergic skin inflammation mediated by FcεRI cross-linking in Nmu-/-mice was inhibited by prior injection of NMU. These results indicate that NMU plays an important physiological role as a negative regulator during the late stage of IgE-mediated allergic skin inflammation. |
| first_indexed | 2024-04-14T00:06:40Z |
| format | Article |
| id | doaj.art-5f47ed4034524a90a74ba98537e650f4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T00:06:40Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5f47ed4034524a90a74ba98537e650f42022-12-22T02:23:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01117e016012210.1371/journal.pone.0160122Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation.Yoshiko MizukawaTakaaki DoiYoshimi YamazakiAkihiko KudoTetsuo ShioharaAlthough keratinocyte-derived neuropeptide neuromedin U (NMU) mediates the proinflammatory effects of innate-type mast cell activation, no information is available on the physiological roles. Here, to investigate the effects of NMU on IgE-mediated allergic skin inflammation, we determined whether IgE-mediated inflammation associated with severe scratching was induced in Nmu-/- mice administered repeated hapten applications to the ear or footpad. Dry skin was induced by targeted deletion of Nmu. Mice administered repeated hapten application developed IgE-mediated allergic inflammation characterized by severe scratching and increased serum IgE levels only when the ear, and not the footpad, was subjected to scratching, indicating that depletion of NMU from the epidermis alone does not drive such allergic inflammation. Thus, the susceptibility of Nmu-/- mice to allergic inflammation depends primarily on scratching dry skin. Further, allergic skin inflammation mediated by FcεRI cross-linking in Nmu-/-mice was inhibited by prior injection of NMU. These results indicate that NMU plays an important physiological role as a negative regulator during the late stage of IgE-mediated allergic skin inflammation.http://europepmc.org/articles/PMC4963095?pdf=render |
| spellingShingle | Yoshiko Mizukawa Takaaki Doi Yoshimi Yamazaki Akihiko Kudo Tetsuo Shiohara Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. PLoS ONE |
| title | Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. |
| title_full | Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. |
| title_fullStr | Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. |
| title_full_unstemmed | Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. |
| title_short | Epidermal Neuromedin U Attenuates IgE-Mediated Allergic Skin Inflammation. |
| title_sort | epidermal neuromedin u attenuates ige mediated allergic skin inflammation |
| url | http://europepmc.org/articles/PMC4963095?pdf=render |
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