Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone
The aim of this review was to identify a new potential explanation for the development of macular holes in relation to the female sex and to explain the possible underlying pathways. This approach was based on the evaluation of anatomical, physiological, and morphological analyses currently availabl...
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MDPI AG
2023-07-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/8/400 |
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| author | Nousal Wergenthaler H. Burkhard Dick Teresa Tsai Stephanie C. Joachim |
| author_facet | Nousal Wergenthaler H. Burkhard Dick Teresa Tsai Stephanie C. Joachim |
| author_sort | Nousal Wergenthaler |
| collection | DOAJ |
| description | The aim of this review was to identify a new potential explanation for the development of macular holes in relation to the female sex and to explain the possible underlying pathways. This approach was based on the evaluation of anatomical, physiological, and morphological analyses currently available in the literature. The findings showed that estrogen exerts a protective effect on the neuroretina and may influence Müller and cone cells. Both cell types are responsible for the building of the fovea structure. However, this protection may be lost due to the sudden decrease in estrogen levels during menopause. In conclusion, the fovea cones, through its sensitivity to estrogen and high energy consumption, may be very vulnerable to damage caused by a sudden changes in the concentration of estrogen in menopausal females. Such changes may result in cone degeneration, and thus a destroyed structure of the fovea, and may lead to the development of a hole in the fovea, as in the case of macular holes. This review revealed that under the decreasing influence of estrogen may cones play a key role with regard to the etiology of the development of macular holes. This aspect may be of strategic importance in prophylactic therapy for the prevention of the development of macular holes in premenopausal females or after ocular trauma. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T00:02:12Z |
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| spelling | doaj.art-5f49382e06de41dda6a2d04ae5237be52023-11-19T00:41:40ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-07-014586339635110.3390/cimb45080400Etiology of Idiopathic Macular Holes in the Light of Estrogen HormoneNousal Wergenthaler0H. Burkhard Dick1Teresa Tsai2Stephanie C. Joachim3Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, GermanyExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, GermanyExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, GermanyExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, GermanyThe aim of this review was to identify a new potential explanation for the development of macular holes in relation to the female sex and to explain the possible underlying pathways. This approach was based on the evaluation of anatomical, physiological, and morphological analyses currently available in the literature. The findings showed that estrogen exerts a protective effect on the neuroretina and may influence Müller and cone cells. Both cell types are responsible for the building of the fovea structure. However, this protection may be lost due to the sudden decrease in estrogen levels during menopause. In conclusion, the fovea cones, through its sensitivity to estrogen and high energy consumption, may be very vulnerable to damage caused by a sudden changes in the concentration of estrogen in menopausal females. Such changes may result in cone degeneration, and thus a destroyed structure of the fovea, and may lead to the development of a hole in the fovea, as in the case of macular holes. This review revealed that under the decreasing influence of estrogen may cones play a key role with regard to the etiology of the development of macular holes. This aspect may be of strategic importance in prophylactic therapy for the prevention of the development of macular holes in premenopausal females or after ocular trauma.https://www.mdpi.com/1467-3045/45/8/400idiopathic macular holeestrogencone photoreceptormitochondria |
| spellingShingle | Nousal Wergenthaler H. Burkhard Dick Teresa Tsai Stephanie C. Joachim Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone Current Issues in Molecular Biology idiopathic macular hole estrogen cone photoreceptor mitochondria |
| title | Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone |
| title_full | Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone |
| title_fullStr | Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone |
| title_full_unstemmed | Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone |
| title_short | Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone |
| title_sort | etiology of idiopathic macular holes in the light of estrogen hormone |
| topic | idiopathic macular hole estrogen cone photoreceptor mitochondria |
| url | https://www.mdpi.com/1467-3045/45/8/400 |
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