Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters
Background: Obesity has become one of the most common metabolic disorders in the world, characterized by the accumulation of excess fat in the body. Research into natural compounds to improve obesity has become increasingly important. Aims and Objectives: The aim of the study was to explore the e...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2024-04-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/61882 |
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| author | Soh Nde Florent Ghomdim Nzali Horliane Ejoh Aba Richard Tchiegang Clergé |
| author_facet | Soh Nde Florent Ghomdim Nzali Horliane Ejoh Aba Richard Tchiegang Clergé |
| author_sort | Soh Nde Florent |
| collection | DOAJ |
| description | Background: Obesity has become one of the most common metabolic disorders in the world, characterized by the accumulation of excess fat in the body. Research into natural compounds to improve obesity has become increasingly important.
Aims and Objectives: The aim of the study was to explore the effects of Sardina pilchardus and Ricinodendron heudelotii oils on the management of obesity.
Materials and Methods: Njansan (R. heudelotii) oil was extracted by cold pressing using an automatic oil press machine and Sardine fish oil by a cooking method. To evaluate the anti-obesity effect of these oils, six groups of six male Wistar rats were fed different diets: C0 group received a normal diet; HFD was fed a high-fat diet; N1, N2, F1 and F2 followed by a high-fat diet supplemented with njansan and sardine oils at 1 g/kg body weight/day and 2 g/kg body weight/day, respectively.
Results: There was an increase in body weight, relative abdominal fat, and liver weight in the HFD group compared to the control group. There was also a decrease in anthropometric parameters such as the Lee index of the HFD group treated with njansan and fish oils, regardless of the concentration. The hyperlipidemic state in the HFD-fed rats was then normalized after treatment with both oils as well as hyperglycemia compared to the control group. Besides, fish and njansan oils attenuated HFD-induced oxidative stress, as indicated by a significant increase CA and superoxide dismutase.
Conclusion: This study demonstrated that njansan oils at a low daily dose (1 g/kg body weight) can be helpful in managing obesity and also reduce the risk of developing coronary heart diseases. |
| first_indexed | 2024-04-24T15:24:26Z |
| format | Article |
| id | doaj.art-5f49f3d161754105ad51eb9f3069e1cb |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-24T15:24:26Z |
| publishDate | 2024-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-5f49f3d161754105ad51eb9f3069e1cb2024-04-02T06:40:08ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762024-04-011545869https://doi.org/10.3126/ajms.v15i4.61882Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parametersSoh Nde Florent 0https://orcid.org/0009-0001-8255-1281Ghomdim Nzali Horliane 1https://orcid.org/0000-0002-7079-426XEjoh Aba Richard 2https://orcid.org/0000-0002-6852-2265Tchiegang Clergé 3https://orcid.org/0000-0001-9528-7718Student, Department of Nutrition, Food and Bioresource Technology, College of Technology, The University of Bamenda, Bambili, Cameroon Assistant Professor, Department of Food Process and Quality Control, Bioprocess Laboratory, University Institute of Technology (UIT), University of Ngaoundere, Adamaoua, Cameroon Professor, Department of Nutrition, Food and Bioresource Technology, College of Technology, The University of Bamenda, Bambili, Cameroon Professor, Department of Food Process and Quality Control, Bioprocess Laboratory, University Institute of Technology (UIT), University of Ngaoundere, Adamaoua, Cameroon Background: Obesity has become one of the most common metabolic disorders in the world, characterized by the accumulation of excess fat in the body. Research into natural compounds to improve obesity has become increasingly important. Aims and Objectives: The aim of the study was to explore the effects of Sardina pilchardus and Ricinodendron heudelotii oils on the management of obesity. Materials and Methods: Njansan (R. heudelotii) oil was extracted by cold pressing using an automatic oil press machine and Sardine fish oil by a cooking method. To evaluate the anti-obesity effect of these oils, six groups of six male Wistar rats were fed different diets: C0 group received a normal diet; HFD was fed a high-fat diet; N1, N2, F1 and F2 followed by a high-fat diet supplemented with njansan and sardine oils at 1 g/kg body weight/day and 2 g/kg body weight/day, respectively. Results: There was an increase in body weight, relative abdominal fat, and liver weight in the HFD group compared to the control group. There was also a decrease in anthropometric parameters such as the Lee index of the HFD group treated with njansan and fish oils, regardless of the concentration. The hyperlipidemic state in the HFD-fed rats was then normalized after treatment with both oils as well as hyperglycemia compared to the control group. Besides, fish and njansan oils attenuated HFD-induced oxidative stress, as indicated by a significant increase CA and superoxide dismutase. Conclusion: This study demonstrated that njansan oils at a low daily dose (1 g/kg body weight) can be helpful in managing obesity and also reduce the risk of developing coronary heart diseases.https://www.nepjol.info/index.php/AJMS/article/view/61882obesity; high-fat diet; njansan oil; sardine oil; lipid profile; antioxidant parameters |
| spellingShingle | Soh Nde Florent Ghomdim Nzali Horliane Ejoh Aba Richard Tchiegang Clergé Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters Asian Journal of Medical Sciences obesity; high-fat diet; njansan oil; sardine oil; lipid profile; antioxidant parameters |
| title | Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters |
| title_full | Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters |
| title_fullStr | Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters |
| title_full_unstemmed | Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters |
| title_short | Oral supplementation of Njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters |
| title_sort | oral supplementation of njansan ricinodendron heudelotii bail and sardine fillets sardina pilchardus oils alleviate high fat diet induced obesity in rats by regulating lipid metabolism and stress oxidative parameters |
| topic | obesity; high-fat diet; njansan oil; sardine oil; lipid profile; antioxidant parameters |
| url | https://www.nepjol.info/index.php/AJMS/article/view/61882 |
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