Studying early structural changes in SOS1 mediated KRAS activation mechanism

KRAS activation is known to be modulated by a guanine nucleotide exchange factor (GEF), namely, Son of Sevenless1 (SOS1). SOS1 facilitates the exchange of GDP to GTP thereby leading to activation of KRAS. The binding of GDP/GTP to KRAS at the REM/allosteric site of SOS1 regulates the activation of K...

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Bibliographic Details
Main Authors: Kirti Bhadhadhara, Vinod Jani, Shruti Koulgi, Uddhavesh Sonavane, Rajendra Joshi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Structural Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X23000211