TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways

TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways

Background: Cardiac fibrosis is the most important pathogenesis leading to cardiac remodeling and heart failure after myocardial infarction (MI). Tissue nonspecific alkaline phosphatase (TNAP) has recently been recognized as a potential prognostic factor for MI. Nevertheless, the role of TNAP in car...

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Bibliographic Details
Main Authors: Xiaocheng Cheng, Liyou Wang, Xuesong Wen, Lei Gao, Guoxing Li, Guanglei Chang, Shu Qin, Dongying Zhang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:EBioMedicine
Subjects:
TNAP
Myocardial infarction
Cardiac fibrosis
TGF-β1/Smads
ERK1/2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001638

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http://www.sciencedirect.com/science/article/pii/S2352396421001638

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