Metformin sensitises osteosarcoma to chemotherapy <em>via</em> the IGF-1R/miR-610/FEN1 pathway

Metformin sensitises osteosarcoma to chemotherapy <em>via</em> the IGF-1R/miR-610/FEN1 pathway

Metformin can enhance cancer cell chemosensitivity to anticancer drugs. IGF-1R is involved in cancer chemoresistance. The current study aimed to elucidate the role of metformin in osteosarcoma (OS) cell chemosensitivity modulation and identify its underlying mechanism in IGF-1R/miR-610/FEN1 signall...

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Bibliographic Details
Main Authors: Suwei Dong, Yanbin Xiao, Ziqiang Zhu, Xiang Ma, Zhuohui Peng, Jianping Kang, Jianqiang Wang, Yunqing Wang, Zhen Li
Format: Article
Language:English
Published: PAGEPress Publications 2023-05-01
Series:European Journal of Histochemistry
Subjects:
osteosarcoma
metformin
IGF-1R
FEN1
chemosensitivity
Online Access:https://www.ejh.it/index.php/ejh/article/view/3612

Internet

https://www.ejh.it/index.php/ejh/article/view/3612

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