Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA

Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA

Abstract Background Directed DNA methylation on N6-adenine (6mA), N4-cytosine (4mC), and C5-cytosine (5mC) can potentially increase DNA coding capacity and regulate a variety of biological functions. These modifications are relatively abundant in bacteria, occurring in about a percent of all bases o...

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Bibliographic Details
Main Authors: Zach K. O’Brown, Konstantinos Boulias, Jie Wang, Simon Yuan Wang, Natasha M. O’Brown, Ziyang Hao, Hiroki Shibuya, Paul-Enguerrand Fady, Yang Shi, Chuan He, Sean G. Megason, Tao Liu, Eric L. Greer
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Genomics
Subjects:
DNA epigenome
DNA N6-methyladenosine
6 mA
DNA N4-methylcytosine
4mC
Online Access:http://link.springer.com/article/10.1186/s12864-019-5754-6

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http://link.springer.com/article/10.1186/s12864-019-5754-6

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