Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors

Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors

Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy (ACT) against solid tumors. Here, we present a facile immune cell surface engineering strategy aiming to substantially enhance the anti-tumor efficacy of Th9-mediated ACT by rapidly identifying...

Full description

Bibliographic Details
Main Authors: Tao Chen, Yucheng Xue, Shengdong Wang, Jinwei Lu, Hao Zhou, Wenkan Zhang, Zhiyi Zhou, Binghao Li, Yong Li, Zenan Wang, Changwei Li, Yinwang Eloy, Hangxiang Sun, Yihang Shen, Mohamed Diaty Diarra, Chang Ge, Xupeng Chai, Haochen Mou, Peng Lin, Xiaohua Yu, Zhaoming Ye
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-05-01
Series:Bioactive Materials
Subjects:
Adoptive cell therapy (ACT)
Phage display
Cell surface engineering
Th9 cell
Solid tumor
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22004868

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X22004868

Similar Items