Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization

Abstract Although Alzheimer’s disease (AD) is characterized by distinct pathological changes, their precise impact on cortical functions are not well understood. Here we used TASTPM mice as an AD model and asked whether the development of neurodegenerative changes has an impact on the extracellular...

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Bibliographic Details
Main Authors: Fátima Gimeno-Ferrer, Annett Eitner, Noor Noora, Reinhard Bauer, Christoph Schmidt-Hieber, Hans-Georg Schaible, Frank Richter
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-57868-4