Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that ident...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2013-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/19/7/13-0313_article |
| _version_ | 1819263111837777920 |
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| author | Suzanne M. Hingley-Wilson Rosalyn Casey David Connell Samuel Bremang Jason T. Evans Peter M. Hawkey Grace E. Smith Annette Jepson Stuart Philip Onn Min Kon Ajit Lalvani |
| author_facet | Suzanne M. Hingley-Wilson Rosalyn Casey David Connell Samuel Bremang Jason T. Evans Peter M. Hawkey Grace E. Smith Annette Jepson Stuart Philip Onn Min Kon Ajit Lalvani |
| author_sort | Suzanne M. Hingley-Wilson |
| collection | DOAJ |
| description | Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance. |
| first_indexed | 2024-12-23T20:08:24Z |
| format | Article |
| id | doaj.art-5f72ad35721e4da483bbe6b8dc4c7ed4 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-23T20:08:24Z |
| publishDate | 2013-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-5f72ad35721e4da483bbe6b8dc4c7ed42022-12-21T17:32:52ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592013-07-011971138114110.3201/eid1907.130313Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed InfectionSuzanne M. Hingley-WilsonRosalyn CaseyDavid ConnellSamuel BremangJason T. EvansPeter M. HawkeyGrace E. SmithAnnette JepsonStuart PhilipOnn Min KonAjit LalvaniInfections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.https://wwwnc.cdc.gov/eid/article/19/7/13-0313_articleMycobacterium tuberculosisco-infectiontreatment resistancemultidrug resistantdrug sensitivetuberculosis and other mycobacteria |
| spellingShingle | Suzanne M. Hingley-Wilson Rosalyn Casey David Connell Samuel Bremang Jason T. Evans Peter M. Hawkey Grace E. Smith Annette Jepson Stuart Philip Onn Min Kon Ajit Lalvani Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection Emerging Infectious Diseases Mycobacterium tuberculosis co-infection treatment resistance multidrug resistant drug sensitive tuberculosis and other mycobacteria |
| title | Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection |
| title_full | Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection |
| title_fullStr | Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection |
| title_full_unstemmed | Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection |
| title_short | Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection |
| title_sort | undetected multidrug resistant tuberculosis amplified by first line therapy in mixed infection |
| topic | Mycobacterium tuberculosis co-infection treatment resistance multidrug resistant drug sensitive tuberculosis and other mycobacteria |
| url | https://wwwnc.cdc.gov/eid/article/19/7/13-0313_article |
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