Predictable fibroblast tension generation by measuring compaction of anchored collagen matrices using microscopy and optical coherence tomography

The anchored fibroblast-populated collagen matrix (aFPCM) is an appropriate model to study fibrocontractive disease mechanisms. Our goal was to determine if aFPCM height reduction (compaction) during development is sufficient to predict tension generation. Compaction was quantified daily by both tra...

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Bibliographic Details
Main Authors: Melville B. Vaughan, Gang Xu, Tracy L. Morris, Pratiksha Kshetri, Jing X. Herwig
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Cell Adhesion & Migration
Subjects:
Online Access:http://dx.doi.org/10.1080/19336918.2019.1644855