Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC

Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC

Predominant inflammatory immunological patterns as well as the depletion of CD4<sup>+</sup> T cells during nonalcoholic fatty liver disease (NAFLD) are reported to be associated with the progression of hepatocellular carcinoma (HCC). Here, we report that an LRP-1 agonistic peptide, SP16,...

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Bibliographic Details
Main Authors: Madison Isbell, Faridoddin Mirshahi, Hussein F. Aqbi, Chunqing Guo, Mulugeta Saneshaw, Nicholas Koelsch, Michael O. Idowu, Dana Austin, Cohava Gelber, Xiang-Yang Wang, Arun J. Sanyal, Masoud H. Manjili
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
tumor microenvironment
hepatocellular carcinoma
NAFLD
inflammation
immunological pattern
Online Access:https://www.mdpi.com/2072-6694/14/22/5502

Internet

https://www.mdpi.com/2072-6694/14/22/5502

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