Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC
Predominant inflammatory immunological patterns as well as the depletion of CD4<sup>+</sup> T cells during nonalcoholic fatty liver disease (NAFLD) are reported to be associated with the progression of hepatocellular carcinoma (HCC). Here, we report that an LRP-1 agonistic peptide, SP16,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/22/5502 |
| _version_ | 1797465771394203648 |
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| author | Madison Isbell Faridoddin Mirshahi Hussein F. Aqbi Chunqing Guo Mulugeta Saneshaw Nicholas Koelsch Michael O. Idowu Dana Austin Cohava Gelber Xiang-Yang Wang Arun J. Sanyal Masoud H. Manjili |
| author_facet | Madison Isbell Faridoddin Mirshahi Hussein F. Aqbi Chunqing Guo Mulugeta Saneshaw Nicholas Koelsch Michael O. Idowu Dana Austin Cohava Gelber Xiang-Yang Wang Arun J. Sanyal Masoud H. Manjili |
| author_sort | Madison Isbell |
| collection | DOAJ |
| description | Predominant inflammatory immunological patterns as well as the depletion of CD4<sup>+</sup> T cells during nonalcoholic fatty liver disease (NAFLD) are reported to be associated with the progression of hepatocellular carcinoma (HCC). Here, we report that an LRP-1 agonistic peptide, SP16, when administered during advanced NAFLD progression, restored the depleted CD4<sup>+</sup> T cell population but did not significantly affect the inflammatory immunological pattern. This data suggests that restoration of CD4<sup>+</sup> T cells without modulation of the hepatic immunological pattern is not sufficient to prevent HCC. However, SP16 administered early during NAFLD progression modulated the inflammatory profile. Future studies will determine if regulation of the inflammatory immune response by SP16 early in NAFLD progression will prevent HCC. |
| first_indexed | 2024-03-09T18:26:20Z |
| format | Article |
| id | doaj.art-5f795be7162b4aca94f6e445292889be |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:20Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5f795be7162b4aca94f6e445292889be2023-11-24T07:52:15ZengMDPI AGCancers2072-66942022-11-011422550210.3390/cancers14225502Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCCMadison Isbell0Faridoddin Mirshahi1Hussein F. Aqbi2Chunqing Guo3Mulugeta Saneshaw4Nicholas Koelsch5Michael O. Idowu6Dana Austin7Cohava Gelber8Xiang-Yang Wang9Arun J. Sanyal10Masoud H. Manjili11Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USADepartment of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USADepartment of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USAVCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USADepartment of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USADepartment of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USAVCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USASerpin Pharma, 9501 Discovery Blvd., Suite 120, Manassas, VA 20109, USASerpin Pharma, 9501 Discovery Blvd., Suite 120, Manassas, VA 20109, USAVCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USAVCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USADepartment of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USAPredominant inflammatory immunological patterns as well as the depletion of CD4<sup>+</sup> T cells during nonalcoholic fatty liver disease (NAFLD) are reported to be associated with the progression of hepatocellular carcinoma (HCC). Here, we report that an LRP-1 agonistic peptide, SP16, when administered during advanced NAFLD progression, restored the depleted CD4<sup>+</sup> T cell population but did not significantly affect the inflammatory immunological pattern. This data suggests that restoration of CD4<sup>+</sup> T cells without modulation of the hepatic immunological pattern is not sufficient to prevent HCC. However, SP16 administered early during NAFLD progression modulated the inflammatory profile. Future studies will determine if regulation of the inflammatory immune response by SP16 early in NAFLD progression will prevent HCC.https://www.mdpi.com/2072-6694/14/22/5502tumor microenvironmenthepatocellular carcinomaNAFLDinflammationimmunological pattern |
| spellingShingle | Madison Isbell Faridoddin Mirshahi Hussein F. Aqbi Chunqing Guo Mulugeta Saneshaw Nicholas Koelsch Michael O. Idowu Dana Austin Cohava Gelber Xiang-Yang Wang Arun J. Sanyal Masoud H. Manjili Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC Cancers tumor microenvironment hepatocellular carcinoma NAFLD inflammation immunological pattern |
| title | Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC |
| title_full | Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC |
| title_fullStr | Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC |
| title_full_unstemmed | Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC |
| title_short | Restoration of CD4<sup>+</sup> T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC |
| title_sort | restoration of cd4 sup sup t cells during nafld without modulation of the hepatic immunological pattern is not sufficient to prevent hcc |
| topic | tumor microenvironment hepatocellular carcinoma NAFLD inflammation immunological pattern |
| url | https://www.mdpi.com/2072-6694/14/22/5502 |
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