Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis

Background Mounting evidence indicates that melatonin has possible activity against different tumors. Pazopanib is an anticancer drug used to treat renal cell carcinoma (RCC). This study tested the anticancer activity of melatonin combined with pazopanib on RCC cells and explored the underlying mech...

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Bibliographic Details
Main Authors: Chien-Pin Lai, Yong-Syuan Chen, Tsung-Ho Ying, Cheng-Yen Kao, Hui-Ling Chiou, Shao-Hsuan Kao, Yi-Hsien Hsieh
Format: Article
Language:English
Published: The Korean Society of Nephrology 2023-07-01
Series:Kidney Research and Clinical Practice
Subjects:
Online Access:http://www.krcp-ksn.org/upload/pdf/j-krcp-22-114.pdf