Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate. We explored the signal transduction pathways of chondrocyte proliferation and matrix sy...

Full description

Bibliographic Details
Main Authors: Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Periodic mechanical stress
Chondrocyte proliferation and matrix synthesis
Src
PLCγ1
MEK1/2-ERK1/2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200006&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200006&lng=en&tlng=en

Similar Items