Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate. We explored the signal transduction pathways of chondrocyte proliferation and matrix sy...

Full description

Bibliographic Details
Main Authors:	Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2011-12-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Periodic mechanical stress Chondrocyte proliferation and matrix synthesis Src PLCγ1 MEK1/2-ERK1/2
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200006&lng=en&tlng=en

Similar Items

Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity
by: Wenwei Liang, et al.
Published: (2013-10-01)

Periodic Mechanical Stress Stimulates GIT1-Dependent Mitogenic Signals in Rat Chondrocytes Through ERK1/2 Activity
by: Kewei Ren, et al.
Published: (2018-10-01)

PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?
by: Rossi Gian, et al.
Published: (2011-06-01)

Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence
by: Karla del Valle Ramírez, Pre-doc, et al.
Published: (2021-06-01)

Tegaserod Maleate Suppresses the Growth of Gastric Cancer In Vivo and In Vitro by Targeting MEK1/2
by: Zitong Wang, et al.
Published: (2022-07-01)

Structural and functional characterization of the divergent Entamoeba Src using Src inhibitor-1
by: Luilli López-Contreras, et al.
Published: (2017-10-01)

Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2
by: Lili Zhao, et al.
Published: (2022-12-01)

Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway
by: Zejia Yang, et al.
Published: (2019-05-01)

UBTF facilitates melanoma progression via modulating MEK1/2-ERK1/2 signalling pathways by promoting GIT1 transcription
by: Jian Zhang, et al.
Published: (2021-10-01)

Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer
by: Xueli Tian, et al.
Published: (2022-10-01)

Periodic Mechanical Stress Stimulates Cav-1-Dependent IGF-1R Mitogenic Signals in Rat Chondrocytes Through ERK1/2
by: Kewei Ren, et al.
Published: (2018-08-01)

Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells
by: Guangyan Kan, et al.
Published: (2021-05-01)

Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers
by: Boya Li, et al.
Published: (2022-06-01)

Cardiac Hormones Target the Ras-MEK 1/2-ERK 1/2 Kinase Cancer Signaling Pathways
by: David L. Vesely
Published: (2011-03-01)

Azelnidipine may be a valuable drug for chemoprevention of ESCC with high MEK1/2 levels
by: Haili Qian
Published: (2022-12-01)

Pharmacologic inhibition of MEK1/2 reduces lung inflammation without impairing bacterial clearance in experimental Pseudomonas aeruginosa pneumonia
by: Matthew E. Long, et al.
Published: (2017-09-01)

Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma
by: Juan Du, et al.
Published: (2020-12-01)

PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL‐1β‐treated rat chondrocytes
by: Xiaolei Chen, et al.
Published: (2021-02-01)

Extracellular Vesicle Activation of Latent HIV-1 Is Driven by EV-Associated c-Src and Cellular SRC-1 via the PI3K/AKT/mTOR Pathway
by: Robert A. Barclay, et al.
Published: (2020-06-01)

The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation
by: Dimitrios Toumpanakis, et al.
Published: (2017-12-01)

Statin-Sensitive Akt1/Src/Caveolin-1 Signaling Enhances Oxidative Stress Resistance in Rhabdomyosarcoma
by: Silvia Codenotti, et al.
Published: (2024-02-01)

Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents
by: Ping Xu, et al.
Published: (2013-05-01)

Rigosertib inhibits MEK1–ERK pathway and alleviates lipopolysaccharide‐induced sepsis
by: Yin Wang, et al.
Published: (2021-09-01)

Knockdown of PAF1 reduces cervical cancer cell proliferation, migration and invasion via retarding FLOT2-mediated MEK/ERK1/2 pathway
by: Bin Tang, et al.
Published: (2023-12-01)

Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia
by: Hu J, et al.
Published: (2022-08-01)

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway
by: Myun Soo Kim, et al.
Published: (2022-01-01)

Periodic Mechanical Stress Induces Extracellular Matrix Expression and Migration of Rat Nucleus Pulposus Cells Through Src-GIT1-ERK1/2 Signaling Pathway
by: Gongming Gao, et al.
Published: (2018-10-01)

Src activates retrograde membrane traffic through phosphorylation of GBF1
by: Joanne Chia, et al.
Published: (2021-12-01)

Two splice variants of the DsMEK1 mitogen-activated protein kinase kinase (MAPKK) are involved in salt stress regulation in Dunaliella salina in different ways
by: Ziyi Tang, et al.
Published: (2020-08-01)

Potential roles of MEK1 on aging in Argopecten scallops
by: Ke Yuan, et al.
Published: (2022-11-01)

The protective role of omentin-1 in IL-1β-induced chondrocyte senescence
by: Bin Chai, et al.
Published: (2020-01-01)

IKBKE-driven TPL2 and MEK1 phosphorylations sustain constitutive ERK1/2 activation in tumor cells
by: Serkan Ismail Göktuna
Published: (2022-02-01)

SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC
by: Man Yuan, et al.
Published: (2019-07-01)

Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells
by: Ryo Ito, et al.
Published: (2016-03-01)

Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development
by: Lara M. Schüssele, et al.
Published: (2022-12-01)

Domperidone inhibits cell proliferation via targeting MEK and CDK4 in esophageal squamous cell carcinoma
by: Qiang Yuan, et al.
Published: (2024-03-01)

Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells
by: Liang Chen, et al.
Published: (2019-04-01)

Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1α, and COL2A1 gene expression
by: Duygu Yasar Sirin, et al.
Published: (2018-02-01)

Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells
by: Yanling Fan, et al.
Published: (2019-05-01)

Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway
by: Pui-Kei Wu, et al.
Published: (2020-07-01)