Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor

Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor

Glucocorticoids (GCs) are hormones involved in circadian adaptation and stress response, and it is also noteworthy that these steroidal molecules present potent anti-inflammatory action through GC receptors (GR). Upon ligand-mediated activation, GR translocates to the nucleus, and regulates gene exp...

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Bibliographic Details
Main Authors: Ester da Silva Pinheiro, André Maciel Preato, Tamirez Villas Boas Petrucci, Lucas Souza dos Santos, Isaias Glezer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Endocrinology
Subjects:
immune response
liquid-liquid phase separation (LLPS)
steroid receptors
transcription control
transregulation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1160238/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1160238/full

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