Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor
Glucocorticoids (GCs) are hormones involved in circadian adaptation and stress response, and it is also noteworthy that these steroidal molecules present potent anti-inflammatory action through GC receptors (GR). Upon ligand-mediated activation, GR translocates to the nucleus, and regulates gene exp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1160238/full |
| _version_ | 1827967597983825920 |
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| author | Ester da Silva Pinheiro André Maciel Preato Tamirez Villas Boas Petrucci Lucas Souza dos Santos Isaias Glezer |
| author_facet | Ester da Silva Pinheiro André Maciel Preato Tamirez Villas Boas Petrucci Lucas Souza dos Santos Isaias Glezer |
| author_sort | Ester da Silva Pinheiro |
| collection | DOAJ |
| description | Glucocorticoids (GCs) are hormones involved in circadian adaptation and stress response, and it is also noteworthy that these steroidal molecules present potent anti-inflammatory action through GC receptors (GR). Upon ligand-mediated activation, GR translocates to the nucleus, and regulates gene expression related to metabolism, acute-phase response and innate immune response. GR field of research has evolved considerably in the last decades, providing varied mechanisms that contributed to the understanding of transcriptional regulation and also impacted drug design for treating inflammatory diseases. Liquid-liquid phase separation (LLPS) in cellular processes represents a recent topic in biology that conceptualizes membraneless organelles and microenvironments that promote, or inhibit, chemical reactions and interactions of protein or nucleic acids. The formation of these molecular condensates has been implicated in gene expression control, and recent evidence shows that GR and other steroid receptors can nucleate phase separation (PS). Here we briefly review the varied mechanisms of transcriptional control by GR, which are largely studied in the context of inflammation, and further present how PS can be involved in the control of gene expression. Lastly, we consider how the reported advances on LLPS during transcription control, specially for steroid hormone receptors, could impact the different modalities of GR action on gene expression, adding a new plausible molecular event in glucocorticoid signal transduction. |
| first_indexed | 2024-04-09T18:07:53Z |
| format | Article |
| id | doaj.art-5f814225cf3d44a284811bda4e2471d9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T18:07:53Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5f814225cf3d44a284811bda4e2471d92023-04-14T05:20:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11602381160238Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptorEster da Silva PinheiroAndré Maciel PreatoTamirez Villas Boas PetrucciLucas Souza dos SantosIsaias GlezerGlucocorticoids (GCs) are hormones involved in circadian adaptation and stress response, and it is also noteworthy that these steroidal molecules present potent anti-inflammatory action through GC receptors (GR). Upon ligand-mediated activation, GR translocates to the nucleus, and regulates gene expression related to metabolism, acute-phase response and innate immune response. GR field of research has evolved considerably in the last decades, providing varied mechanisms that contributed to the understanding of transcriptional regulation and also impacted drug design for treating inflammatory diseases. Liquid-liquid phase separation (LLPS) in cellular processes represents a recent topic in biology that conceptualizes membraneless organelles and microenvironments that promote, or inhibit, chemical reactions and interactions of protein or nucleic acids. The formation of these molecular condensates has been implicated in gene expression control, and recent evidence shows that GR and other steroid receptors can nucleate phase separation (PS). Here we briefly review the varied mechanisms of transcriptional control by GR, which are largely studied in the context of inflammation, and further present how PS can be involved in the control of gene expression. Lastly, we consider how the reported advances on LLPS during transcription control, specially for steroid hormone receptors, could impact the different modalities of GR action on gene expression, adding a new plausible molecular event in glucocorticoid signal transduction.https://www.frontiersin.org/articles/10.3389/fendo.2023.1160238/fullimmune responseliquid-liquid phase separation (LLPS)steroid receptorstranscription controltransregulation |
| spellingShingle | Ester da Silva Pinheiro André Maciel Preato Tamirez Villas Boas Petrucci Lucas Souza dos Santos Isaias Glezer Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor Frontiers in Endocrinology immune response liquid-liquid phase separation (LLPS) steroid receptors transcription control transregulation |
| title | Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor |
| title_full | Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor |
| title_fullStr | Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor |
| title_full_unstemmed | Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor |
| title_short | Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor |
| title_sort | phase separation a possible new layer for transcriptional regulation by glucocorticoid receptor |
| topic | immune response liquid-liquid phase separation (LLPS) steroid receptors transcription control transregulation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1160238/full |
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