CXCL8(3–72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway

CXCL8(3–72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway

Abstract Background Acute kidney injury (AKI), which is mainly caused by sepsis, has high morbidity and mortality rates. CXCL8(3–72) K11R/G31P (G31P) can exert therapeutic effect on inflammatory diseases and malignancies. We aimed to investigate the effect and mechanism of G31P on septic AKI. Method...

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Bibliographic Details
Main Authors: Yunfeng Zhou, Wenda Xu, Hong Zhu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Biological Research
Subjects:
G31P
AKI
Inflammation
NF-κB
JAK2
STAT3
Online Access:http://link.springer.com/article/10.1186/s40659-019-0236-5

Internet

http://link.springer.com/article/10.1186/s40659-019-0236-5

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