Parallel evolution of methyltransferases leads to vobasine biosynthesis in Tabernaemontana elegans and Catharanthus roseus

Parallel evolution of methyltransferases leads to vobasine biosynthesis in Tabernaemontana elegans and Catharanthus roseus

Monoterpenoid indole alkaloids (MIA) are one of the largest and most complex alkaloid class in nature, boasting many clinically significant drugs such as anticancer vinblastine and antiarrhythmic ajmaline. Many MIAs undergo nitrogen N-methylation, altering their reactivity and affinity to the biolog...

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Bibliographic Details
Main Authors: Maisha Farzana, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Zhan Mai, Destiny Ichechi Njoku, Ghislain Deslongchamps, Yang Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Plant Science
Subjects:
monoterpenoid indole alkaloid
methyltransferase
Tabernaemontana elegans
natural product biosynthesis
parallel evolution
vobasine
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2024.1451298/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2024.1451298/full

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