Detection of Nonsynonymous Single Variants in Human HLA-DRB1 Exon 2 Associated with Renal Transplant Rejection

Detection of Nonsynonymous Single Variants in Human HLA-DRB1 Exon 2 Associated with Renal Transplant Rejection

<i>Background</i>: HLA-DRB1 is the most polymorphic gene in the human leukocyte antigen (HLA) class II, and exon 2 is critical because it encodes antigen-binding sites. This study aimed to detect functional or marker genetic variants of HLA-DRB1 exon 2 in renal transplant recipients (acc...

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Bibliographic Details
Main Authors: Mohamed M. Hassan, Mohamed A. Hussain, Sababil S. Ali, Mohammed A. Mahdi, Nouh Saad Mohamed, Hanadi AbdElbagi, Osama Mohamed, Asmaa E. Sherif, Wadah Osman, Sabrin R. M. Ibrahim, Kholoud F. Ghazawi, Samar F. Miski, Gamal A. Mohamed, Ahmed Ashour
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Medicina
Subjects:
graft rejection
HLA-DRB1 gene
renal diseases
single nucleotide variants snvs
DNA sequencing
HLA typing
Online Access:https://www.mdpi.com/1648-9144/59/6/1116

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https://www.mdpi.com/1648-9144/59/6/1116

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