Three-Component Coupling Reactions of Arynes for the Synthesis of Benzofurans and Coumarins

The domino three-component coupling reaction of arynes with DMF and active methylenes or methines was studied as a highly efficient method for preparing heterocycles. Coumarin derivative 5 was formed when diethyl malonate (2) or α-bromomalonate (3) were used as a C2-unit. In contrast, dihydrobenzo...

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Bibliographic Details
Main Authors: Eito Yoshioka, Shigeru Kohtani, Hideto Miyabe
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/19/1/863