Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

Antisense oligonucleotides conjugated with boron clusters (B-ASOs) have been described as potential gene expression inhibitors and carriers of boron for boron neutron capture therapy (BNCT), providing a dual-action therapeutic platform. In this study, we tested the nucleolytic stability of DNA oligo...

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Bibliographic Details
Main Authors: Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus, Zbigniew Lesnikowski, Barbara Nawrot
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomolecules
Subjects:
antisense oligonucleotide
metallacarborane
boron cluster
snake venom
phosphodiesterase
exonuclease
Online Access:https://www.mdpi.com/2218-273X/10/5/718

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