Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets

In a search of small molecules active against apoptosis-resistant cancer cells, including glioma, melanoma, and non-small cell lung cancer, we previously prepared α,β- and γ,δ-unsaturated ester analogues of polygodial and ophiobolin A, compounds capable of pyrrolylation of primary amines and demonst...

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Bibliographic Details
Main Authors: Vladimir Maslivetc, Breana Laguera, Sunena Chandra, Ramesh Dasari, Wesley J. Olivier, Jason A. Smith, Alex C. Bissember, Marco Masi, Antonio Evidente, Veronique Mathieu, Alexander Kornienko
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
anticancer activity
apoptosis resistance
ophiobolin A
polygodial
Wittig reaction
Online Access:https://www.mdpi.com/1422-0067/22/20/11256

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https://www.mdpi.com/1422-0067/22/20/11256

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