Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease

Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease

Abstract Background Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence rates and severity of progression. The cellular and molecular mechanisms underlying this clinical phenomenon remain elusive and ill-defined. Me...

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Bibliographic Details
Main Authors: Deng Wu, Xiaoman Bi, Kim Hei-Man Chow
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Sex dimorphism
Late-onset Alzheimer’s disease
Estrogen receptor signaling
Bioinformatics
Online Access:https://doi.org/10.1186/s12974-023-02987-4

Internet

https://doi.org/10.1186/s12974-023-02987-4

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