Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway

Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway

Summary: Currently, no mouse models manifest calcification and thrombus formation, which is frequently associated with human atherosclerosis. We demonstrated that lack of Favine/CCDC3 in apoE knockout mice accelerated atherosclerosis accompanied by large cholesterol crystals and calcification, and a...

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Bibliographic Details
Main Authors: Sachiko Kobayashi, Shunbun Kita, Daisuke Okuzaki, Yuya Fujishima, Michio Otsuki, Hisashi Kato, Yasuko Nishizawa, Kazuya Miyashita, Chieko Yokoyama, Atsunori Fukuhara, Eiichi Morii, Iichiro Shimomura
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
biological sciences
molecular biology
health sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015243

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http://www.sciencedirect.com/science/article/pii/S2589004222015243

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