Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients

Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients

Abstract Parkinson’s disease (PD) is a neurodegenerative disease with both genetic and sporadic origins. In this study, we investigated the electrophysiological properties, synaptic activity, and gene expression differences in dopaminergic (DA) neurons derived from induced pluripotent stem cells (iP...

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Bibliographic Details
Main Authors: Idan Rosh, Utkarsh Tripathi, Yara Hussein, Wote Amelo Rike, Jose Djamus, Boris Shklyar, Andreea Manole, Henry Houlden, Jurgen Winkler, Fred H. Gage, Shani Stern
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00653-x

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https://doi.org/10.1038/s41531-024-00653-x

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