Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

Abstract Background In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer’s disease (LOAD) and translate the associations to causation. Methods We conducted ATAC-seq profiling using NeuN sorted-nuclei from 40 frozen brain tissues to determ...

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Bibliographic Details
Main Authors: Julio Barrera, Lingyun Song, Julia E. Gamache, Melanie E. Garrett, Alexias Safi, Young Yun, Ivana Premasinghe, Daniel Sprague, Danielle Chipman, Jeffrey Li, Hélène Fradin, Karen Soldano, Raluca Gordân, Allison E. Ashley-Koch, Gregory E. Crawford, Ornit Chiba-Falek
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Molecular Neurodegeneration
Subjects:
ATAC-seq
Chromatin accessibility
Nuclei sorting
Late-onset Alzheimer’s disease
snRNA-seq
Gene dysregulation
Online Access:https://doi.org/10.1186/s13024-021-00481-0

Internet

https://doi.org/10.1186/s13024-021-00481-0

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