Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice
Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/4/1194 |
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| author | Paola D. D. S. Maia Diego dos Santos Baião Hayandra F. Nanini Victor Paulo F. da Silva Lissa Bantim Frambach Iuri Matheus Cabral Beatriz Pêgo Beatriz E. Ribeiro Mauro Sérgio Gonçalves Pavão Vania M. F. Paschoalin Heitor S. P. de Souza Anna Paola T. R. Pierucci |
| author_facet | Paola D. D. S. Maia Diego dos Santos Baião Hayandra F. Nanini Victor Paulo F. da Silva Lissa Bantim Frambach Iuri Matheus Cabral Beatriz Pêgo Beatriz E. Ribeiro Mauro Sérgio Gonçalves Pavão Vania M. F. Paschoalin Heitor S. P. de Souza Anna Paola T. R. Pierucci |
| author_sort | Paola D. D. S. Maia |
| collection | DOAJ |
| description | Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs were extracted and quantified from pure beer samples. BALB/c mice received either the beer phenolic extract (BPE) or beer powder fortified with phenolic extract (BPFPE) of PCs daily for 20 days by gavage. Colon samples were collected for histopathological and immunohistochemical analyses. Dextran sodium sulfate (DSS)-induced mice lost more weight, had reduced colon length, and developed more inflammatory changes compared with DSS-induced mice treated with either BPE or BPFPE. In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-κB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated. Pretreatment with the phenolic extract and BPFPE remarkably attenuated DSS-induced colitis. The protective effect of PCs supports further investigation and development of therapies for human IBD. |
| first_indexed | 2024-03-09T21:21:44Z |
| format | Article |
| id | doaj.art-5f9324771a934baeac507dbd1c66da35 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:21:44Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5f9324771a934baeac507dbd1c66da352023-11-23T21:20:13ZengMDPI AGMolecules1420-30492022-02-01274119410.3390/molecules27041194Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c MicePaola D. D. S. Maia0Diego dos Santos Baião1Hayandra F. Nanini2Victor Paulo F. da Silva3Lissa Bantim Frambach4Iuri Matheus Cabral5Beatriz Pêgo6Beatriz E. Ribeiro7Mauro Sérgio Gonçalves Pavão8Vania M. F. Paschoalin9Heitor S. P. de Souza10Anna Paola T. R. Pierucci11Basic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 393, Rio de Janeiro 21941-590, BrazilInstitute of Chemistry, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos, 149, Rio de Janeiro 21941-909, BrazilDepartment of Clinical Medicine, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, 11th floor, Rio de Janeiro 21941-617, BrazilBasic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 393, Rio de Janeiro 21941-590, BrazilBasic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 393, Rio de Janeiro 21941-590, BrazilBasic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 393, Rio de Janeiro 21941-590, BrazilDepartment of Clinical Medicine, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, 11th floor, Rio de Janeiro 21941-617, BrazilDepartment of Clinical Medicine, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, 11th floor, Rio de Janeiro 21941-617, BrazilInstitute of Medical Biochemistry, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, 4th floor, Rio de Janeiro 21941-617, BrazilInstitute of Chemistry, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos, 149, Rio de Janeiro 21941-909, BrazilDepartment of Clinical Medicine, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, 11th floor, Rio de Janeiro 21941-617, BrazilBasic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 393, Rio de Janeiro 21941-590, BrazilPhenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs were extracted and quantified from pure beer samples. BALB/c mice received either the beer phenolic extract (BPE) or beer powder fortified with phenolic extract (BPFPE) of PCs daily for 20 days by gavage. Colon samples were collected for histopathological and immunohistochemical analyses. Dextran sodium sulfate (DSS)-induced mice lost more weight, had reduced colon length, and developed more inflammatory changes compared with DSS-induced mice treated with either BPE or BPFPE. In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-κB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated. Pretreatment with the phenolic extract and BPFPE remarkably attenuated DSS-induced colitis. The protective effect of PCs supports further investigation and development of therapies for human IBD.https://www.mdpi.com/1420-3049/27/4/1194bioactive compoundsexperimental colitis<i>Pale Ale</i> beer powderphenolic acids |
| spellingShingle | Paola D. D. S. Maia Diego dos Santos Baião Hayandra F. Nanini Victor Paulo F. da Silva Lissa Bantim Frambach Iuri Matheus Cabral Beatriz Pêgo Beatriz E. Ribeiro Mauro Sérgio Gonçalves Pavão Vania M. F. Paschoalin Heitor S. P. de Souza Anna Paola T. R. Pierucci Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice Molecules bioactive compounds experimental colitis <i>Pale Ale</i> beer powder phenolic acids |
| title | Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice |
| title_full | Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice |
| title_fullStr | Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice |
| title_full_unstemmed | Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice |
| title_short | Bioactive Compounds from <i>Pale Ale</i> Beer Powder Attenuate Experimental Colitis in BALB/c Mice |
| title_sort | bioactive compounds from i pale ale i beer powder attenuate experimental colitis in balb c mice |
| topic | bioactive compounds experimental colitis <i>Pale Ale</i> beer powder phenolic acids |
| url | https://www.mdpi.com/1420-3049/27/4/1194 |
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