Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?

Abstract Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease in neurogenesis. Transplantation of mesenchymal cells or cultured NSCs has been st...

Full description

Bibliographic Details
Main Authors: Yoshitaka Kase, Takuya Shimazaki, Hideyuki Okano
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Inflammation and Regeneration
Subjects:
Online Access:http://link.springer.com/article/10.1186/s41232-020-00122-x