A new flow cytometry assay identifies recipient IgG subtype antibodies binding donor cells: increasing donor availability for highly sensitised patients

A new flow cytometry assay identifies recipient IgG subtype antibodies binding donor cells: increasing donor availability for highly sensitised patients

Abstract Objectives There are four immunoglobulin (IgG) subtypes that have varying complement‐activating ability: strong (IgG3 and IgG1) and weak (IgG2 and IgG4). The standard flow cytometric crossmatch (FCM) assay does not distinguish between the various subtypes of the IgG molecule. This study out...

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Bibliographic Details
Main Authors: Prakash N Rao, Dayanand D Deo, Amitabh Gaur, David A Baran, Mark J Zucker, Saurabh Kapoor, Misty A Marchioni, Jesus Almendral, Praveen Kandula, Anup Patel
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
complement activation
flow crossmatch
IgG subtypes
sensitised patients
transplant
Online Access:https://doi.org/10.1002/cti2.1415

Internet

https://doi.org/10.1002/cti2.1415

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