A new flow cytometry assay identifies recipient IgG subtype antibodies binding donor cells: increasing donor availability for highly sensitised patients
Abstract Objectives There are four immunoglobulin (IgG) subtypes that have varying complement‐activating ability: strong (IgG3 and IgG1) and weak (IgG2 and IgG4). The standard flow cytometric crossmatch (FCM) assay does not distinguish between the various subtypes of the IgG molecule. This study out...
Main Authors: | Prakash N Rao, Dayanand D Deo, Amitabh Gaur, David A Baran, Mark J Zucker, Saurabh Kapoor, Misty A Marchioni, Jesus Almendral, Praveen Kandula, Anup Patel |
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Format: | Article |
Language: | English |
Published: |
Wiley
2022-01-01
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Series: | Clinical & Translational Immunology |
Subjects: | |
Online Access: | https://doi.org/10.1002/cti2.1415 |
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