Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search for new, effective and safe antimalarial drugs is c...

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Bibliographic Details
Main Authors: Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2018-06-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Malaria
Plasmodium falciparum
multicomponent reactions
Biginelli reaction
pyrimidinones
molecular modelling
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000800301&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000800301&lng=en&tlng=en

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