Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4−/− Mice

Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4−/− Mice

Danger-associated molecular patterns are released by damaged cells and trigger neuroinflammation through activation of non-specific pattern recognition receptors, e.g., toll-like receptors (TLRs). Since the role of TLR2 and 4 after traumatic brain injury (TBI) is still unclear, we examined the outco...

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Bibliographic Details
Main Authors: Sandro M. Krieg, Florian Voigt, Pascal Knuefermann, Carsten Jürgen Kirschning, Nikolaus Plesnila, Florian Ringel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neurology
Subjects:
toll-like receptors
brain edema
intracranial pressure
secondary brain damage
traumatic brain injury
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00455/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00455/full

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