Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms

Therapy-related myeloid neoplasms (t-MN) are a growing concern due to the continued use of cytotoxic therapies to treat malignancies. Cytotoxic therapies have been shown to drive therapy-induced senescence in normal tissues, including in the bone marrow microenvironment (BMME), which plays a crucial...

Full description

Bibliographic Details
Main Authors: Angelo Jose Guilatco, Mithun Vinod Shah, Megan Moore Weivoda
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Journal of Bone Oncology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137424001003